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KMID : 0604519990250040111
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Journal of the Society of Cosmetic Scientists of Korea
1999 Volume.25 No. 4 p.111 ~ p.121
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STUDIES OF ACNE TREATMENT USING ORIENTAL HERBS
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Nam, Chunju
Han, Y.G./Kim, S.J./Kim, J.H./Oh, J.Y/Park, J.W./Lee, H.
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Abstract
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Acne vulgaris, the most common skin disease, can be formed as only a few comedons or severe inflammatory lesions. The pathogenesis of acne involves various factors: excessive androgen, excessive sebum production, abnormal alteration of follicular epithelium, proliferation of Propionibacteriunt aches, and inflammation. We investigated acne therapy using oriental herbs described in the Korean traditional medical book (Dong-ui-bo-gam). Oriental herbs (Angelica daurica. Arclium lappa. Coptidis rhizoma and Glvcyrrhiza glabra) were chosen based on their respective property of sebum control, anti-inflammatory activity, and anti-bacterial activity. We examined the effect of acne treatment, in terms of chemotactic inhibition, lipogenesis inhibition, and anti-bacterial activity for P. anes. 1. Neutrophil chemotaxis assay P. acnes secrete chemotactic factors and other pro-inflammatory extraceilular products. Neutrophil chemotactic activity of P. acnes was measured by 48-well chemotaxis method. Angelica daurica cleariy suppressed chemotactic activity of P. acnes. 2. Using sebaceous gland of hamster ear lipogenesis assay, Sebaceous lipogenesis was measured using ear biopsies by incubation of C^(14)-acetate in culture media. The C^(14)- labeled lipids were extracted and determined by liquid scintilation counting. Coptidis rhizoma markedly inhibited sebum production. 3. Anti-bacterial assay for P. acnes (MIC test) Glycyrrhizaglabra showed antibacterial activity. P. acnes did not develop resistance against Glycyrrhiza glahra.
Retinoids are effectively to inhibit sebum production and regulate follicular keratinization process, with little anti-inflammatory activity. Angelica daurica suppressed neutrophil chemotaxis, Coplldis rhizoma inhibited sebum production, and Glvcyrrhiza glahra showed anti-bacterial activity against P aches. A combined formulation of Angelica daurica. Coptidis rhizoma. and Clvcyrrhiza glabra is expected toprovide effective acne treatment.
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